Potentiation of artemisinin activity against chloroquine-resistant Plasmodium falciparum strains by using heme models.
نویسندگان
چکیده
The influence of different metalloporphyrin derivatives on the antimalarial activity of artemisinin was studied with two chloroquine-resistant strains of Plasmodium falciparum (FcB1-Colombia and FcM29-Cameroon) cultured in human erythrocytes. This potentiation study indicates that the manganese complex of meso-tetrakis(4-sulfonatophenyl)porphyrin has a significant synergistic effect on the activity of artemisinin against both Plasmodium strains.
منابع مشابه
Extracellular heme enhances the antimalarial activity of artemisinin.
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Endoperoxide antimalarials based on the ancient Chinese drug Qinghaosu (artemisinin) are currently our major hope in the fight against drug-resistant malaria. Rational drug design based on artemisinin and its analogues is slow as the mechanism of action of these antimalarials is not clear. Here we report that these drugs, at least in part, exert their effect by interfering with the plasmodial h...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 43 10 شماره
صفحات -
تاریخ انتشار 1999